Understanding GLP-1 Medications: Simple Explained

GLP-1 medications are revolutionizing weight loss. Here's everything you need to know in simple terms.

What Are GLP-1 Medications?

GLP-1 medications are injectable drugs that mimic a natural hormone (GLP-1) your body already makes. This hormone:

• Signals your brain that you're full
• Slows digestion so you stay satisfied longer
• Regulates blood sugar levels
• Reduces food cravings

The medications work by providing higher, longer-lasting levels of this hormone than your body produces naturally.

How Do They Work for Weight Loss?

1. Appetite Suppression

• You feel full faster
• Less interest in food between meals
• Reduced cravings for sweets and fatty foods

2. Slower Digestion

• Food stays in stomach longer
• Prolonged feeling of fullness
• Eat less at each meal naturally

3. Blood Sugar Control

• More stable energy levels
• Fewer hunger spikes from blood sugar crashes
• Better insulin function

Popular GLP-1 Medications

Semaglutide (Ozempic/Wegovy)

• Weight loss: Average 15-17% body weight
• Dosing: Once weekly injection
• Cost: $200-400/month (compounded) or $1,300-1,500 (brand)
• Best for: Proven track record, most studied

Tirzepatide (Mounjaro/Zepbound)

• Weight loss: Average 20-22% body weight
• Dosing: Once weekly injection
• Cost: $300-500/month (compounded) or $1,000-1,400 (brand)
• Best for: Highest weight loss results, dual mechanism

Liraglutide (Saxenda)

• Weight loss: Average 8-10% body weight
• Dosing: Daily injection
• Cost: $1,300-1,500/month
• Best for: Daily injection preference, lower cost with insurance

Who Can Use GLP-1 Medications?

You may qualify if:

• BMI ≥30 (obese)
• BMI ≥27 with weight-related health condition
• Age 18+ years
• Previous weight loss attempts unsuccessful

Cannot use if you have:

• Personal/family history of thyroid cancer
• Pregnant or planning pregnancy
• History of pancreatitis
• Certain stomach/intestinal problems

What to Expect

Timeline:

• Week 1: Reduced appetite
• Month 1: 5-10 pounds lost
• Month 3: 10-20 pounds lost
• Month 6: 15-25 pounds lost
• Month 12: 25-45 pounds lost

Common side effects:

• Nausea (usually mild and temporary)
• Occasional vomiting or diarrhea
• Constipation
• Reduced appetite (this is the goal!)

Most side effects improve after first few weeks as body adjusts.

How Long Do You Take It?

• Weight loss phase: 6-18 months
• Maintenance: Many continue long-term at lower dose
• Stopping: Weight may return if lifestyle not maintained

Semaglutide vs Tirzepatide: Quick Comparison

Choose Semaglutide if:

• You want proven, well-studied option
• Looking for lower cost
• 15-17% weight loss is your goal

Choose Tirzepatide if:

• You want maximum weight loss (20-22%)
• Budget allows slightly higher cost
• Dual mechanism appeals to you

Cost Considerations

• Brand name with insurance: $25-100/month
• Brand name without insurance: $900-1,500/month
• Compounded (online): $200-500/month
• Typical treatment duration: 6-12 months minimum

Bottom Line

GLP-1 medications are safe, effective tools for weight loss when used under medical supervision. They work by mimicking natural hormones to reduce appetite and help you eat less. With average weight loss of 15-22% body weight, they're among the most effective non-surgical options available.

Frequently Asked Questions