Retatrutide at Trimi: Why We Offer the Triple Agonist

Trimi's mission is to make the most effective weight loss treatments accessible and affordable. Retatrutide, the world's first triple agonist with up to 24.2% body weight loss in Phase 2 trials (Jastreboff et al., NEJM 2023), represents the next frontier in obesity medicine. Here is why Trimi is committed to offering this breakthrough treatment and how it fits into our comprehensive approach to weight management.

Why Triple Agonism Matters

Retatrutide is not just an incremental improvement over existing GLP-1 medications. It represents a paradigm shift. By activating GLP-1, GIP, and glucagon receptors simultaneously, it addresses obesity through the most comprehensive mechanism yet developed. The glucagon component adds energy expenditure and fat oxidation that single and dual agonists cannot provide. This means more weight loss, potentially better metabolic outcomes, and a new option for patients who have plateaued on other medications.

At Trimi, we believe patients deserve access to the best available treatments, not just the most marketed ones. As retatrutide becomes available, we are committed to making it accessible at affordable prices, consistent with our approach to semaglutide and tirzepatide.

The Trimi Approach

Medical-First Philosophy

Every Trimi patient receives a comprehensive medical evaluation before starting any GLP-1 medication. Our providers review medical history, current medications, contraindications, and individual goals to determine the right treatment. This personalized approach becomes even more important with retatrutide, whose triple mechanism requires understanding of metabolic, hormonal, and neurological effects.

Affordable Access

Brand-name GLP-1 medications cost $1,000-1,500+ monthly. Trimi's commitment to affordability makes treatment realistic for patients who would otherwise be priced out. Our current pricing reflects this mission:

• Compounded semaglutide: $99/month
• Compounded tirzepatide: $125/month
• Retatrutide: Pricing to be announced when available, consistent with our affordability mission

Ongoing Medical Support

GLP-1 treatment is not just a prescription. Trimi provides dose titration guidance based on individual response, side effect management and treatment adjustment, medication interaction review, nutritional and lifestyle guidance, and regular check-ins and lab monitoring.

Current Treatment Options at Trimi

While retatrutide availability develops, Trimi offers two proven GLP-1 medications:

Compounded Semaglutide ($99/month)

The same active ingredient as Ozempic and Wegovy. Produces 15-17% average body weight loss. Extensive safety data from millions of patients. FDA-approved molecule with the longest GLP-1 track record.

Compounded Tirzepatide ($125/month)

The same active ingredient as Mounjaro and Zepbound. Dual agonist (GLP-1 + GIP) producing 22-25% weight loss. Currently the most effective FDA-approved weight loss medication. Shares two of three receptor targets with retatrutide.

Transitioning to Retatrutide

When retatrutide becomes available at Trimi, patients on semaglutide or tirzepatide will have the option to transition. Our medical team will guide the switch, including appropriate washout periods, restarting at appropriate doses, and monitoring for the unique effects of glucagon receptor activation. Starting treatment now with semaglutide or tirzepatide is the best approach: you benefit immediately and can upgrade to retatrutide when it becomes available.

Get Started Today

Do not wait for retatrutide to begin your weight loss journey. Explore Trimi's current treatment options and start with compounded semaglutide ($99/month) or compounded tirzepatide ($125/month). Learn how Trimi works.

Frequently Asked Questions

Does Trimi currently offer retatrutide?

Trimi is actively preparing to offer retatrutide as availability expands. Currently, we offer compounded semaglutide ($99/month) and compounded tirzepatide ($125/month) as proven GLP-1 treatment options.

How much will retatrutide cost at Trimi?

Pricing will be announced when retatrutide becomes available through our pharmacy partners. Consistent with our mission, we will work to make it as affordable as possible.

Should I start semaglutide now or wait for retatrutide?

Start now. Semaglutide and tirzepatide produce excellent weight loss results, and delaying treatment allows obesity-related health risks to worsen. You can transition to retatrutide when it becomes available.

Is Trimi's compounded medication safe?

Trimi partners with accredited compounding pharmacies that follow strict quality standards. All medications are prescribed by licensed providers after medical evaluation and are manufactured from pharmaceutical-grade ingredients.