Semaglutide Results Timeline: Week by Week Guide
Medically Reviewed
Dr. Michael Chen
MD, Board Certified in Obesity Medicine
Weight Management
Last reviewed: November 26, 2025
Wondering when you'll see results on semaglutide? Here's a realistic week-by-week timeline based on clinical data and patient experiences.
Week 1-2: Initial Effects
What to expect:
- Appetite: Noticeably reduced within 2-3 days
- Weight loss: 0-2 pounds (mostly water weight)
- Side effects: Mild nausea possible
- Energy: May feel slightly tired as body adjusts
Dose: 0.25mg weekly (starting dose)
Week 3-4: Early Weight Loss
What to expect:
- Weight loss: 2-4 pounds total
- Appetite: Consistently lower, smaller portions satisfying
- Cravings: Reduced, especially for sweets and fatty foods
- Side effects: Usually minimal at this dose
Dose: Still 0.25mg (dose increases at month 2)
Month 2: Dose Increase
What to expect:
- Weight loss: 4-8 pounds total (1-2 lbs/week)
- Appetite: Further reduced with dose increase
- Clothes: Noticing looser fit
- Side effects: May return briefly with dose increase
Dose: Increase to 0.5mg weekly
Month 3: Noticeable Changes
What to expect:
- Weight loss: 10-15 pounds total
- Visible changes: Face, waist, and overall body composition
- Energy: Often improved as weight drops
- Blood markers: Blood sugar and blood pressure improving
Dose: May stay at 0.5mg or increase to 1mg
Month 4-6: Steady Progress
What to expect:
- Weight loss: 15-25 pounds total (5-8% body weight)
- Pattern: Consistent 1-2 lbs loss per week
- Habits: New eating patterns feel natural
- Others notice: Friends and family commenting on changes
Dose: Typically 1mg, sometimes increased to 1.7mg
Month 7-12: Maximum Results
What to expect:
- Weight loss: 25-40+ pounds total (10-15% body weight)
- Peak loss: Usually around month 9-12
- Plateau periods: Normal, don't get discouraged
- Maintenance: Transitioning to weight maintenance phase
Dose: Maintenance dose (1.7mg or 2.4mg weekly)
Factors Affecting Your Timeline
Faster results:
- Higher starting weight
- Following lower-calorie diet
- Regular exercise routine
- Good sleep and stress management
Slower results:
- Lower starting weight
- Metabolic conditions (hypothyroid, PCOS)
- Certain medications
- Sedentary lifestyle
Average Total Weight Loss
Based on clinical trials:
- 6 months: 10-12% body weight
- 12 months: 15-17% body weight
- 18+ months: Up to 20% body weight
Example: 200 lb person typically loses 20-24 lbs by month 6, 30-34 lbs by month 12.
Track Your Progress
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Get StartedFrequently Asked Questions
When will I see results on semaglutide?
Most people notice reduced appetite within days. Visible weight loss typically starts in week 3-4, with significant results by month 3-6.
How much weight can I lose in the first month?
Average first-month weight loss is 4-8 pounds. Some lose more, others less depending on starting weight, diet, and exercise.
Does everyone lose the same amount of weight?
No, results vary significantly. Clinical trials show average 15% total body weight loss, but range is typically 10-20% over 12+ months.
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