Your First Month on Tirzepatide: What to Expect Week by Week
Medically Reviewed
Dr. Sean Arora, MD
MD, board-certified physician
GLP-1 Therapeutics & Metabolic Medicine
Last reviewed: May 4, 2026
Related Reading
Related reading: tirzepatide dosing chart.
Start your first month right
Begin a clinician-guided tirzepatide program
Individual results vary and treatment is guided by your provider.
Start your online visitWhen to Contact Your Healthcare Provider
It's important to stay in communication with your healthcare provider throughout your tirzepatide journey. Contact them if you experience any of the following:
- Severe or persistent nausea, vomiting, or diarrhea
- Signs of an allergic reaction, such as rash, itching, or swelling
- Severe abdominal pain
- Changes in vision
- Symptoms of depression or anxiety
More on Tirzepatide Getting Started
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Sources & References
- Wilding JPH et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. NEJM 2021;384:989-1002.
- Jastreboff AM et al. Tirzepatide Once Weekly for the Treatment of Obesity. NEJM 2022;387:205-216.
- Lincoff AM et al. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes. NEJM 2023;389:2221-2232.
- FDA Prescribing Information for Wegovy (semaglutide) and Zepbound (tirzepatide).
Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before starting any medication or treatment program.