Best GLP-1 for Weight Loss: 2025 Comparisons and Choices
Compare semaglutide, tirzepatide, and other GLP-1 medications for weight loss. Updated 2025 rankings based on clinical data, cost, and real-world results.
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2025 GLP-1 Rankings for Weight Loss
Based on the latest clinical trial data, real-world evidence, and meta-analyses, here are our rankings for GLP-1 medications for weight loss in 2025:
Tirzepatide (Mounjaro/Zepbound)
The dual GIP/GLP-1 agonist leads all medications for weight loss efficacy. Learn more in our complete tirzepatide guide.
Semaglutide (Wegovy/Ozempic)
The most widely prescribed and studied GLP-1 for weight loss. Excellent efficacy with the longest safety record. See our semaglutide guide.
Liraglutide (Saxenda)
The original GLP-1 approved for obesity. Less effective than newer options but well-studied with a strong safety profile.
Head-to-Head Comparison
| Feature | Tirzepatide | Semaglutide | Liraglutide |
|---|---|---|---|
| Avg Weight Loss | 20-25% | 15-17% | 5-8% |
| Dosing Frequency | Weekly | Weekly | Daily |
| A1c Reduction | 2.0-2.4% | 1.5-1.8% | 1.0-1.2% |
| Brand Cost/Month | $1,000-1,300 | $900-1,100 | $900-1,000 |
| Compounded Available | Limited | Yes ($200-400) | No |
| GI Side Effects | Moderate | Moderate | Moderate-High |
| CV Outcomes Data | Pending | Strong (SELECT) | Neutral (LEADER) |
For detailed cost comparisons, see our complete GLP-1 cost guide.
Choosing the Right GLP-1 for You
Choose Tirzepatide If:
- • You have significant weight to lose (BMI 35+)
- • You have Type 2 diabetes and want maximum A1c reduction
- • Cost is not a primary concern or you have good insurance
- • You have not responded adequately to semaglutide
- • You prefer the most aggressive treatment approach
Choose Semaglutide If:
- • You want a well-studied medication with strong safety data
- • Cardiovascular protection is important to you
- • Cost is a concern (compounded options available)
- • You have moderate weight loss goals (10-20% body weight)
- • You prefer a medication with extensive real-world evidence
Choose Liraglutide If:
- • You prefer daily dosing over weekly injections
- • You need to start with a very gradual titration
- • You have had intolerable side effects with other GLP-1s
- • Your weight loss goals are more modest (5-10%)
Coming in 2025-2026: Next-Generation Options
Retatrutide (Triple Agonist)
GLP-1/GIP/Glucagon receptor agonist showing up to 24% weight loss in Phase 2 trials. Expected FDA decision: 2026.
Oral Tirzepatide
Pill form of tirzepatide in development. Could eliminate need for injections while maintaining efficacy.
Orforglipron
Novel oral GLP-1 showing 14% weight loss. Potential cost advantages over injectables.
CagriSema
Semaglutide + cagrilintide combination showing enhanced weight loss vs semaglutide alone.
Frequently Asked Questions
Which GLP-1 medication produces the most weight loss?
Based on 2025 clinical data, tirzepatide (Mounjaro/Zepbound) produces the highest average weight loss at 20-25% of body weight. Semaglutide (Wegovy/Ozempic) follows at 15-17%, with liraglutide (Saxenda) at 5-8%.
Is tirzepatide better than semaglutide for weight loss?
Clinical trials show tirzepatide produces greater weight loss than semaglutide on average (20-25% vs 15-17%). However, individual responses vary, and some patients respond better to semaglutide. Cost, availability, and side effect tolerance also factor into the best choice.
What is the most affordable GLP-1 for weight loss?
Compounded semaglutide is currently the most affordable option at $200-400/month. Brand-name options range from $900-1,300/month without insurance. See our cost guide for detailed pricing.
Are there new GLP-1 medications coming in 2025?
Yes, several new GLP-1 and combination medications are in late-stage trials, including oral tirzepatide, retatrutide (triple agonist), and orforglipron. These may offer improved efficacy, convenience, or tolerability.
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