GLP-1 Medication Decision Tree: Which Weight Loss Drug Is Right for You?
Interactive decision guide to help you choose between semaglutide, tirzepatide, and retatrutide based on your goals, health conditions, budget, and preferences.
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Quick Answer
For most first-time patients: start with semaglutide ($125/mo). For insulin resistance or aggressive goals: tirzepatide ($125/mo). For maximum results or after plateauing: retatrutide.
Decision Points
What is your primary goal?
Do you have insulin resistance or PCOS?
What is your budget?
Have you tried a GLP-1 before?
Medication Quick Comparison
Semaglutide
$99/mo
- 15-17% weight loss
- Most studied GLP-1
- Best for first-timers
- Most affordable option
Tirzepatide
$125/mo
- 20-22% weight loss
- Dual GIP/GLP-1 action
- Best for insulin resistance
- Best value per pound lost
Retatrutide
Ask us
- 24%+ weight loss
- Triple agonist (GLP-1/GIP/glucagon)
- Maximum efficacy
- For plateaued patients
Medical Disclaimer: This decision guide is for informational purposes. Your Trimi provider will recommend the best medication based on your complete health profile.
Frequently Asked Questions
How do I choose between semaglutide and tirzepatide?
Consider your budget ($125/mo vs $125/mo), weight loss goals (moderate vs aggressive), and health conditions. Tirzepatide may be better for insulin resistance, PCOS, and higher weight loss targets. Semaglutide has a longer safety track record and is more affordable.
Who should consider retatrutide?
Retatrutide may be ideal for patients who have plateaued on semaglutide or tirzepatide, those with very high BMI (40+), patients with fatty liver disease, or those seeking maximum possible weight loss. It works on three receptors instead of one or two.
Can I switch medications if one doesn't work?
Yes. Switching between GLP-1 medications is common and safe. If semaglutide produces insufficient results, upgrading to tirzepatide often restarts weight loss. Your Trimi provider can guide the transition protocol.
Should I start with the cheapest option first?
Starting with semaglutide ($99/mo) is a reasonable approach for many patients. If results are satisfactory, there's no need to switch. If you need more aggressive weight loss, you can upgrade to tirzepatide ($125/mo) at any time.
Find Your Best GLP-1 Match
Compounded semaglutide from $99/mo or tirzepatide from $125/mo.
View Treatment OptionsSources & References
- Wilding JPH et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. NEJM 2021;384:989-1002.
- Jastreboff AM et al. Tirzepatide Once Weekly for the Treatment of Obesity. NEJM 2022;387:205-216.
- Lincoff AM et al. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes. NEJM 2023;389:2221-2232.
- FDA Prescribing Information for Wegovy (semaglutide) and Zepbound (tirzepatide).