Semaglutide vs Tirzepatide vs Retatrutide: Cost Comparison (2026)
Cost is often the deciding factor in GLP-1 medication choice. Brand-name medications can cost $1,000-1,500+ per month, but compounded versions offer the same active ingredients at a fraction of the price. Here is a comprehensive cost comparison to help you make an informed decision.
Medical Disclaimer: This article is for informational purposes only. Prices are approximate and subject to change. Insurance coverage varies by plan. Compounded medications are prepared by licensed pharmacies under FDA oversight.
Monthly Cost Comparison
| Medication | Brand-Name | With Insurance | Compounded (Trimi) |
|---|---|---|---|
| Semaglutide | $900-1,350/mo | $0-300/mo (varies) | $99/mo |
| Tirzepatide | $1,000-1,500/mo | $0-500/mo (varies) | $125/mo |
| Retatrutide | Not yet available | N/A | Contact for pricing |
Cost Per Pound Lost Analysis
Looking at cost-effectiveness by weight loss achieved (based on a 200 lb starting weight, 12-month treatment):
| Metric | Semaglutide (Trimi) | Tirzepatide (Trimi) |
|---|---|---|
| Annual cost | $1,188 | $1,500 |
| Expected weight loss (200 lb patient) | 24-30 lbs (12-15%) | 30-44 lbs (15-22%) |
| Cost per pound lost | $40-50/lb | $34-50/lb |
On a cost-per-pound basis, tirzepatide often provides better value because the additional $26/month produces proportionally more weight loss. However, semaglutide at $99/month remains the most accessible entry point.
Hidden Costs to Consider
- Lab work: $50-200 per panel, recommended every 3-6 months
- Supplements: Protein, electrolytes, multivitamin ($30-80/month recommended)
- Reduced grocery bill: Eating 30-50% less food saves $100-200/month (a hidden offset)
- Reduced medication costs: Eliminating BP, diabetes, or cholesterol medications saves $50-200+/month
Insurance vs. Compounded: Pros and Cons
- Insurance coverage: May be cheaper if covered, but requires prior authorization, can be denied, and is subject to formulary changes
- Compounded (Trimi): Consistent pricing, no prior authorization, no supply shortages, but not covered by insurance
Get the Best Value with Trimi
No insurance hassles, no prior authorization, no surprise costs. Compounded semaglutide is $99/month and compounded tirzepatide is $125/month. Visit our treatment page to start today.
Frequently Asked Questions
Why is compounded GLP-1 so much cheaper?
Brand-name drug pricing reflects R&D costs, marketing expenses, and profit margins of large pharmaceutical companies. Compounding pharmacies produce the same active ingredient without these overhead costs. The result is a medication that costs a fraction of brand-name pricing.
Is cheaper medication lower quality?
No. Compounded medications are prepared by licensed pharmacies that must comply with FDA and state pharmacy board regulations. The active ingredient is the same. The difference is in pricing, not quality.
Can I use HSA/FSA funds for compounded GLP-1?
Yes. Compounded medications prescribed by a licensed provider for a medical condition are typically HSA/FSA eligible. Check with your plan administrator for confirmation.
More on 3-Way Comparisons
Sources & References
- Wilding JPH et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. NEJM 2021;384:989-1002.
- Jastreboff AM et al. Tirzepatide Once Weekly for the Treatment of Obesity. NEJM 2022;387:205-216.
- Lincoff AM et al. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes. NEJM 2023;389:2221-2232.
- FDA Prescribing Information for Wegovy (semaglutide) and Zepbound (tirzepatide).