Side Effects of Semaglutide and Tirzepatide: What to Expect
Table of Contents
What side effects should I expect from semaglutide or tirzepatide?
The most common side effects are gastrointestinal: nausea (30-45%), diarrhea (20-30%), vomiting (15-25%), and constipation (15-25%). These typically peak during the first 4-8 weeks and improve as your body adjusts. Most patients (85-90%) find side effects manageable.
Black Box Warning: Both medications carry a warning for thyroid C-cell tumors. Do not use if you have a history of medullary thyroid carcinoma (MTC) or MEN 2 syndrome.
Common Side Effects Comparison
Nausea: 30-44% (semaglutide), 35-45% (tirzepatide). Diarrhea: 20-30% both. Vomiting: 15-25% both. Constipation: 15-25% both. See semaglutide side effects and tirzepatide side effects.
Managing GI Symptoms
Eat smaller, more frequent meals. Choose bland, low-fat foods. Stay well-hydrated. Ginger may help nausea. Increase fiber gradually for constipation. See managing GI side effects.
When to Seek Medical Help
Emergency: Severe abdominal pain, persistent vomiting, difficulty breathing. Contact provider: Side effects not improving after 4+ weeks, neck lumps, severe mood changes. See when to call your doctor.
People Also Read
Ready to Start Your Weight Loss Journey?
Get started with physician-guided GLP-1 treatment from the comfort of your home.
Get Started TodayWritten by Dr. Sarah Mitchell
MD, Obesity Medicine
Our team of healthcare professionals specializes in weight management and metabolic health, providing evidence-based information to help you make informed decisions about your health journey.