Long-Term Tirzepatide Use: What 72-Week Data Really Tells Us
Table of Contents
When tirzepatide first came to market, one question dominated: "Is this something I'll take forever?" With 72-week data from SURMOUNT trials and real-world experience, we can provide concrete answers.
Key Insights from Extended Treatment Data
- • Safety profile remains consistent through 72 weeks of treatment
- • GI side effects typically diminish significantly after months 3-6
- • Weight loss continues progressively through 60-72 weeks before plateauing
- • Metabolic benefits (HbA1c, lipids, BP) maintain or improve
- • Discontinuation leads to average 14% weight regain within 52 weeks
What the SURMOUNT Trials Actually Showed
The SURMOUNT trial program provides the most comprehensive long-term data on tirzepatide for weight management, with SURMOUNT-1 following patients for 72 weeks (18 months).
More on Long-Term GLP-1 Outcomes
Long-Term Metabolic Benefits of GLP-1
How GLP-1 therapies create lasting improvements in insulin sensitivity and metabolic health.
Maintaining Weight Loss After GLP-1
Evidence-based strategies for sustaining weight loss results after discontinuing medications.
Tirzepatide First Month Guide
Complete guide to your first 30 days on tirzepatide including what to expect.
Ready to Start Your Weight Loss Journey?
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Get Started TodayWritten by Trimi Medical Team
Our team of healthcare professionals specializes in weight management and metabolic health, providing evidence-based information to help you make informed decisions about your health journey.