Data Visualization6 min readUpdated 2026-04-03

    GLP-1 Cost Comparison Infographic: Brand vs Compounded vs Insurance Pricing 2026

    Visual cost breakdown comparing brand-name Ozempic, Wegovy, Mounjaro, and Zepbound with compounded alternatives. See how Trimi saves patients thousands.

    Bottom Line

    Compounded GLP-1 medications through Trimi cost 90-93% less than brand-name options. Semaglutide at $99/mo and tirzepatide at $125/mo provide the same active ingredients at a fraction of the price.

    Monthly Cost Comparison

    OptionMonthlyAnnualSavings vs Brand
    Wegovy (brand semaglutide)$1,349$16,188-
    Zepbound (brand tirzepatide)$1,060$12,720-
    Trimi Semaglutide (compounded)$125$1,188$15,000/yr
    Trimi Tirzepatide (compounded)$125$1,500$11,220/yr

    Brand-name prices represent typical cash-pay without insurance as of 2026. Compounded pricing through Trimi includes medication, consultation, and shipping.

    Cost Per Pound Lost

    Trimi Semaglutide

    ~$3.30

    per pound lost (30 lbs avg / $99 x 10 months)

    Trimi Tirzepatide

    ~$2.84

    per pound lost (44 lbs avg / $125 x 10 months)

    Brand Wegovy

    ~$44.97

    per pound lost (30 lbs avg / $1,349 x 10 months)

    Why Trimi Is the Best Value

    Same active ingredient as brand-name medications
    Licensed, inspected compounding pharmacies
    Board-certified providers included in the price
    Free shipping to your door
    No insurance required, no prior authorizations
    Cancel anytime, no long-term contracts

    Medical Disclaimer: Pricing as of April 2026. Brand-name prices may vary by pharmacy and location. Compounded medications are not FDA-approved finished products but contain FDA-approved active ingredients.

    Frequently Asked Questions

    How much does GLP-1 medication cost per month?

    Brand-name: Wegovy/Ozempic $1,000-1,400/mo without insurance, Mounjaro/Zepbound $1,000-1,200/mo. Compounded through Trimi: semaglutide $99/mo, tirzepatide $125/mo. That is a savings of $900-1,300 per month or $10,800-15,600 per year.

    Why is compounded GLP-1 so much cheaper?

    Compounded medications are made by licensed pharmacies using the same active ingredient but without brand-name markup, marketing costs, or patent premiums. The FDA allows compounding during drug shortages, making affordable access possible.

    Is cheaper compounded GLP-1 less effective?

    No. Compounded semaglutide and tirzepatide contain the same active pharmaceutical ingredient as brand-name versions. They are prepared by licensed, inspected pharmacies. Clinical outcomes are comparable when using equivalent doses.

    How much will I spend over a full year of treatment?

    At Trimi: semaglutide costs $1,188/year ($99 x 12), tirzepatide costs $1,500/year ($125 x 12). Compare to brand-name without insurance: $12,000-16,800/year. You save $10,000-15,000 annually with compounded options.

    Save Thousands on GLP-1 Treatment

    Compounded semaglutide from $99/mo or tirzepatide from $125/mo.

    View Treatment Options

    Sources & References

    1. Wilding JPH et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. NEJM 2021;384:989-1002.
    2. Jastreboff AM et al. Tirzepatide Once Weekly for the Treatment of Obesity. NEJM 2022;387:205-216.
    3. Lincoff AM et al. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes. NEJM 2023;389:2221-2232.
    4. FDA Prescribing Information for Wegovy (semaglutide) and Zepbound (tirzepatide).

    What's the annual cost comparison for GLP-1 medications?

    12-month total cost comparison for GLP-1 access in May 2026 for uninsured cash-pay patients (lowest to highest): Trimi compounded semaglutide $1,188/year on annual billing ($99/mo × 12) < Trimi compounded tirzepatide $1,500/year ($125/mo annual) < LillyDirect tirzepatide vials $4,188/year (5 mg dose, $349 per 4-week supply × 12) < brand Ozempic retail $11,976/year (~$998/mo) < brand Zepbound retail $13,032/year (~$1,086/mo) < brand Mounjaro retail $13,620/year (~$1,135/mo) < brand Wegovy retail $16,188/year (~$1,349/mo). Insured patients with covered brand indication: Manufacturer Savings Cards drop annual cost to $300/year ($25/mo × 12). Compounded telehealth provider comparison (annual rates): Trimi $99 sema, Henry Meds $129, Mochi $135 + $79 membership ($178/mo true cost), Sequence/Form $179, Hims $199, Calibrate $199. Annual savings switching from brand retail to Trimi compounded: ~$11,000-$15,000/year for uninsured cash-pay patients.

    Cheapest annual: Trimi compounded sema $1,188/year.
    Brand retail cash: $11,976-$16,188/year.
    Switching saves $11k-$15k/year for uninsured patients.

    Key Takeaways

    • 12-month total cost comparison for GLP-1 access in May 2026 (uninsured cash-pay): Trimi compounded semaglutide $1,188/year (annual billing) < Trimi compounded tirzepatide $1,500/year < LillyDirect tirzepatide vials $4,188/year (5 mg) < brand Zepbound retail $13,032/year < Mounjaro retail $13,620/year < Ozempic retail $11,976/year < Wegovy retail $16,188/year.
    • Insured patients with covered brand-medication indication: Manufacturer Savings Cards can drop annual cost to $300/year ($25/mo × 12); Medicare/Medicaid beneficiaries are not eligible.
    • Compounded telehealth provider comparison (annual rates): Trimi $99 sema, Henry Meds $129, Mochi $135 + $79 membership ($178 true), Sequence/Form $179, Hims $199, Calibrate $199.
    • Cost stability across doses: Trimi pricing is dose-flat ($99 at every dose). LillyDirect vials are dose-tiered ($349-$599 per 4-week supply). Brand pens are dose-flat at retail.
    • Annual savings switching from brand retail to Trimi compounded: ~$11,000-$15,000/year depending on brand drug.

    Medically Reviewed

    TMRT

    Trimi Medical Review Team

    Clinical review workflow for GLP-1 safety, dosing, and access content

    Team-based medical review process documented in Trimi's Medical Review Policy

    Last reviewed: December 31, 2025

    TCCT

    Written by Trimi Clinical Content Team

    Medical Writers & Healthcare Professionals

    Our clinical content team includes registered nurses, pharmacists, and medical writers who specialize in translating complex medical information into clear, actionable guidance for patients.

    Medically reviewed by Trimi Medical Review Team, Clinical review workflow for GLP-1 safety, dosing, and access content

    What real Trimi patients say

    Verbatim quotes from Trimi's Facebook and Reddit community reviews. First name and last initial preserved per editorial policy.

    Amazing company and care team support! Fast response time, no hidden fees and they actually care enough to work with you and your needs on your weight loss journey. Down 12.5 pounds in 2 months!

    Outcome: Down 12.5 lbs in 2 months

    Sarah MillerFacebook
    Arrived within 24 hours. Easy to use. Comes with everything. The year is so worth it.

    Outcome: Same-day delivery experience

    Veronica LarimoreFacebook

    Editorial Standards

    Trimi publishes patient education using a medical-review workflow, source-based claim checks, and dated updates for fast-changing pricing, access, and safety topics.

    Review our Editorial Policy and Medical Review Policy for more details about sourcing, updates, and reviewer attribution.

    Scientific References

    1. Novo Nordisk (2025). Wegovy (semaglutide) prescribing information. U.S. Food and Drug Administration.Read Study
    2. Eli Lilly and Company (2025). Zepbound (tirzepatide) prescribing information. U.S. Food and Drug Administration.Read Study
    3. Eli Lilly and Company (2025). Mounjaro (tirzepatide) prescribing information. U.S. Food and Drug Administration.Read Study
    4. Eli Lilly and Company (2025). Lilly lowers the price of Zepbound single-dose vials. Lilly Investor Relations.Read Study
    5. U.S. Food and Drug Administration (2025). FDA clarifies policies for compounders as national GLP-1 supply begins to stabilize. FDA.Read Study

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