GLP-1 Dosing Visual Guide: Titration Schedules for Semaglutide, Tirzepatide, and Retatrutide
Visual step-by-step dosing guide showing titration schedules, dose escalation timelines, and what to expect at each dose level for all GLP-1 medications.
More on Data Visualization
Dosing Principle
Start low, go slow. Gradual dose titration over 4-5 months minimizes side effects while building to therapeutic levels. Your Trimi provider guides each step.
Semaglutide Titration ($99/mo)
Tirzepatide Titration ($125/mo)
Titration Tips
Best Practices
- Stay at each dose for minimum 4 weeks
- Inject on the same day each week
- Increase dose only when side effects resolve
- Track side effects at each dose level
When to Pause
- Persistent vomiting at current dose
- Unable to maintain adequate hydration
- Severe abdominal pain
- Contact your Trimi provider before any dose change
Medical Disclaimer: Dosing schedules should be individualized by your healthcare provider. Never change your dose without provider guidance.
Frequently Asked Questions
How does GLP-1 dose titration work?
All GLP-1 medications start at a low dose and gradually increase over weeks to months. This slow titration minimizes side effects by allowing your body to adjust. Semaglutide typically titrates from 0.25mg to 2.4mg over 16-20 weeks. Tirzepatide goes from 2.5mg to 15mg over 20-28 weeks.
Can I increase my dose faster?
Faster titration increases the likelihood and severity of side effects, especially nausea and vomiting. The standard schedule is designed for optimal tolerability. Only increase doses under provider guidance, and never faster than the recommended schedule.
What if I cannot tolerate a dose increase?
Stay at your current dose for an additional 2-4 weeks. If side effects persist, your provider may reduce the dose temporarily. Many patients find they can eventually tolerate higher doses after a longer adjustment period. Not everyone needs the maximum dose.
Do I need to reach the maximum dose?
No. The right dose is the one that produces adequate weight loss with tolerable side effects. Some patients achieve their goals at moderate doses. Your Trimi provider will work with you to find your optimal dose, which may not be the maximum.
Expert-Guided Dosing
Compounded semaglutide from $99/mo or tirzepatide from $125/mo.
View Treatment OptionsSources & References
- Wilding JPH et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. NEJM 2021;384:989-1002.
- Jastreboff AM et al. Tirzepatide Once Weekly for the Treatment of Obesity. NEJM 2022;387:205-216.
- Lincoff AM et al. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes. NEJM 2023;389:2221-2232.
- FDA Prescribing Information for Wegovy (semaglutide) and Zepbound (tirzepatide).