Semaglutide vs Tirzepatide: Key Differences Explained
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Both are effective GLP-1 medications for weight loss, but tirzepatide's dual-action mechanism typically produces greater weight loss results.
Side-by-Side Comparison
| Feature | Semaglutide | Tirzepatide |
|---|---|---|
| Mechanism | GLP-1 receptor agonist | GIP + GLP-1 (dual action) |
| Weight Loss | 12-15% body weight | 15-22% body weight |
| Dosing | Weekly injection | Weekly injection |
| Common Side Effects | Nausea, diarrhea, constipation | Similar, slightly higher nausea |
| Starting Dose | 0.25mg weekly | 2.5mg weekly |
| Max Dose | 2.4mg weekly | 15mg weekly |
How Each Works
Semaglutide (GLP-1 Only)
- • Mimics GLP-1 hormone naturally produced in gut
- • Slows gastric emptying → increased fullness
- • Reduces appetite through brain signals
- • Improves blood sugar control
Tirzepatide (GIP + GLP-1)
- • Activates both GIP and GLP-1 receptors (dual action)
- • GIP amplifies insulin secretion and fat metabolism
- • Enhanced appetite suppression from dual pathways
- • Greater overall metabolic impact
Which Should You Choose?
Consider Semaglutide If:
- • You have a lower BMI or less weight to lose
- • Cost is a primary concern
- • You're more sensitive to side effects
Consider Tirzepatide If:
- • You need maximum weight loss results
- • You have higher BMI or more weight to lose
- • You want dual metabolic benefits
Scientific References
- Wilding JPH, Batterham RL, Calanna S (2021). Once-Weekly Semaglutide in Adults with Overweight or Obesity. New England Journal of Medicine.Read StudyDOI: 10.1056/NEJMoa2032183
- Jastreboff AM, Aronne LJ, Ahmad NN (2022). Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine.Read StudyDOI: 10.1056/NEJMoa2206038
TMT
Written by Trimi Medical Team
Our team of healthcare professionals specializes in weight management and metabolic health, providing evidence-based information to help you make informed decisions.
Medical Disclaimer: This comparison is for educational purposes only. Consult with your healthcare provider to determine which medication is appropriate for your individual needs.