How to Sign Up for Trimi: Complete Medical Assessment Guide

How do I sign up with Trimi and complete their online medical assessment?

Visit trytrimi.com and complete a 10-15 minute online medical assessment. A physician reviews your information within 24 hours (often same-day). If approved, your medication ships within 1-2 days and arrives in 3-5 days. No video call required—it's fully asynchronous.

Published: January 25, 2026

Last updated: April 1, 2026Recently updated

Getting started with Trimi is straightforward and designed for your convenience. This guide walks you through every step of the signup process—from creating your account to receiving your first medication shipment.

Timeline at a Glance

10-15 minAssessment

24 hoursPhysician Review

3-5 daysDelivery

Step 1: Create Your Account

Start by visiting trytrimi.com and clicking "Get Started" or "Start Now." You'll create a secure account with:

Email address – Used for account access and important notifications
Password – Create a secure password for your patient portal
Basic contact info – Name, phone number, and shipping address

Pro Tip: Use an email you check regularly—this is where you'll receive prescription updates, shipment tracking, and care team messages.

Step 2: Complete the Medical Assessment

The medical assessment is where a physician gathers the information needed to determine if semaglutide or tirzepatide is right for you. Plan for about 10-15 minutes to complete it thoughtfully.

Personal & Health History

• Date of birth, sex assigned at birth, height, and current weight
• Weight history and previous weight loss attempts
• Any previous experience with GLP-1 medications
• Allergies and medication sensitivities

Medical Conditions

• Current diagnoses (diabetes, high blood pressure, sleep apnea, etc.)
• History of thyroid conditions or thyroid cancer
• History of pancreatitis or gallbladder issues
• Kidney or liver conditions
• Mental health history

Current Medications

• All prescription medications you're currently taking
• Over-the-counter medications and supplements
• Insulin or other diabetes medications (important for dosing)

Contraindication Screening

• Family history of medullary thyroid carcinoma (MTC)
• Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
• Pregnancy status or plans to become pregnant
• Breastfeeding status

Be Honest & Complete

Accurate information is essential for your safety. The physician uses your responses to identify potential risks and customize your treatment. There's no judgment—we're here to help you succeed safely.

Step 3: Treatment Preferences

After the medical questions, you'll share your treatment preferences:

Medication Preference

Indicate if you prefer semaglutide, tirzepatide, or want the physician to recommend based on your profile. Learn about the differences in our comparison guide.

Weight Loss Goals

Share your target weight or percentage of body weight you'd like to lose. This helps the physician plan your treatment timeline.

Step 4: Physician Review

After you submit your assessment, a board-certified physician reviews your information. Here's what happens:

Comprehensive Review

The physician evaluates your complete health profile, not just BMI, to determine candidacy

Follow-Up (If Needed)

If clarification is needed, the physician may message you or request a brief video call

Treatment Decision

You'll receive an email with the physician's decision and next steps

<24 hrs

Typical review time

Same Day

Common for business hours

100%

Physician reviewed

Step 5: Prescription & Shipping

Once approved, your prescription is sent to our partner pharmacy and your medication ships promptly:

Prescription Sent

Your prescription is transmitted to our FDA-registered pharmacy partner

Medication Prepared

Your personalized dose is compounded and quality-tested (1-2 business days)

Cold-Chain Shipping

Shipped with ice packs in insulated packaging (2-3 business days transit)

Delivered to Your Door

Discreet packaging with tracking—refrigerate promptly upon arrival

Qualification Requirements

While each case is evaluated individually, general qualification criteria include:

Typically Qualify

BMI ≥30 (with or without other conditions)
BMI ≥27 with weight-related condition
Age 18+ and not pregnant/breastfeeding
No contraindicated conditions

May Not Qualify

✗Personal/family history of MTC or MEN2
✗Active pancreatitis
✗Pregnant or breastfeeding
✗Known hypersensitivity to GLP-1s

What Medical Questions Will You Be Asked?

Understanding exactly what the Trimi medical assessment covers can help you prepare and complete it more quickly. The questionnaire is divided into five key areas, each designed to give your physician a complete picture of your health and readiness for GLP-1 therapy.

Medical History Deep Dive

Your physician needs to understand your full health background. You will be asked about any history of cardiovascular disease, stroke, or heart failure. Questions also cover gastrointestinal conditions such as gastroparesis, inflammatory bowel disease, and chronic constipation, since GLP-1 medications can affect gut motility. A history of eating disorders like anorexia or bulimia is also screened, as these conditions require specialized care before starting weight loss medication. Be prepared to share details about any surgeries you have had, particularly bariatric procedures, as these can affect how your body responds to semaglutide or tirzepatide.

Current Medications & Supplements

Drug interactions are one of the most important aspects of the assessment. You will list every prescription medication you currently take, including dosages. This is especially critical if you use insulin or sulfonylureas, since GLP-1 medications can lower blood sugar and your diabetes medication may need adjustment. Blood thinners, thyroid medications, and oral contraceptives are also flagged for review. Over-the-counter medications and herbal supplements matter too—some can interact with GLP-1 receptor agonists or affect how your body absorbs the medication.

Weight History & Previous Attempts

The assessment asks about your weight trajectory over the past several years. How long have you struggled with weight management? Have you tried prescription weight loss medications before, and if so, which ones and what happened? Did you try phentermine, orlistat, or naltrexone-bupropion? Your physician wants to understand what has and has not worked so they can tailor your GLP-1 treatment plan appropriately. If you have previously used semaglutide or tirzepatide at another provider, note the doses you reached and any side effects you experienced. Check our semaglutide eligibility guide for detailed qualification criteria.

Goals & Lifestyle Factors

Beyond the clinical questions, your physician wants to know what success looks like for you. Are you focused on a specific weight target, or are you more interested in improving metabolic markers like A1C and blood pressure? Do you have an upcoming event or health milestone driving your timeline? The assessment also asks about your current activity level, diet patterns, sleep habits, and stress levels, since these factors significantly influence how well GLP-1 therapy works and what supportive recommendations your care team can provide.

Contraindication Screening Questions

The final section of the assessment focuses on absolute and relative contraindications. You will be asked directly about personal or family history of medullary thyroid carcinoma and Multiple Endocrine Neoplasia syndrome type 2, which are absolute contraindications for all GLP-1 medications. Questions about active or recent pancreatitis, severe kidney disease (eGFR below 15), and current pregnancy or breastfeeding are also included. These questions are non-negotiable safety checks that every responsible telehealth provider must conduct before prescribing.

How Trimi's Physicians Review Your Assessment

Once you submit your assessment, the real work begins on the clinical side. Trimi partners exclusively with board-certified physicians who specialize in obesity medicine, endocrinology, or internal medicine. These are not nurse practitioners or physician assistants handling your initial evaluation—a licensed physician with prescribing authority reviews every single assessment personally.

What the Physician Evaluates

BMI & Metabolic Risk Profile

Your BMI is calculated from height and weight, but it is only one data point. The physician also evaluates your waist-to-height ratio indicators, metabolic syndrome markers, and overall cardiometabolic risk to build a complete picture of whether GLP-1 therapy is clinically appropriate.

Drug Interaction Analysis

Every medication you listed is cross-referenced against known interactions with semaglutide and tirzepatide. Particular attention goes to insulin, sulfonylureas, and other glucose-lowering medications where hypoglycemia risk must be managed through coordinated dose adjustments.

Contraindication Clearance

The physician verifies there are no absolute contraindications and assesses relative contraindications (like a history of pancreatitis or gallbladder disease) to determine if benefits outweigh risks for your specific situation.

Medication Selection & Starting Dose

Based on your profile and preferences, the physician selects the appropriate medication and determines your starting dose. First-time patients typically begin at the lowest available dose to minimize side effects and allow your body to adjust gradually.

The physician may also request additional information before making a decision. This could include recent lab work (like an A1C or thyroid panel), a note from your primary care provider, or a brief video consultation to discuss specific concerns. Trimi never charges extra for these follow-up interactions. If the physician determines that GLP-1 therapy is not safe or appropriate for you, you will receive a detailed explanation and will not be charged. For a full overview of the process, visit our how it works page. Understanding Trimi's pricing and subscription model can also help you plan ahead before your assessment is reviewed.

After Approval: Your First Month Timeline

Knowing what to expect after approval helps you prepare and set realistic expectations. Here is a detailed timeline of your first month with Trimi, from the moment you receive your approval notification to your first monthly check-in.

Day 1-3: Prescription & Pharmacy Processing

Within hours of approval, your physician transmits your prescription to Trimi's FDA-registered partner pharmacy. The pharmacy team verifies the prescription, prepares your personalized dose, and conducts quality assurance testing. You will receive an email confirmation that your prescription has been received and is being processed. During this window, you can log into the Trimi patient portal to view your prescription details, set up payment, and confirm your shipping address.

Day 3-7: Shipping & Delivery

Your medication ships via cold-chain logistics with insulated packaging and ice packs to maintain proper temperature. You will receive a tracking number by email and SMS so you can monitor delivery in real time. Most patients receive their medication within 3-5 business days of approval. When it arrives, refrigerate it promptly. Your shipment includes the medication vial, syringes, alcohol swabs, and clear injection instructions. Review our shipping and subscription details for more information on delivery timelines and what is included.

Week 1-2: Starting Your First Dose

Your first injection is a milestone moment. If you have been prescribed semaglutide, you will typically start at 0.25 mg once weekly. For tirzepatide, the usual starting dose is 2.5 mg once weekly. Choose a consistent day of the week for your injection. Common injection sites include the abdomen, thigh, or upper arm. During the first week or two, mild side effects like nausea, decreased appetite, or minor injection site reactions are normal as your body adjusts. Eating smaller meals, staying hydrated, and avoiding greasy or heavy foods can help minimize discomfort. If you are starting tirzepatide, our tirzepatide quick start guide walks you through exactly what to expect.

Week 2-3: Early Adjustments

By your second or third injection, most patients notice reduced appetite and early changes in eating patterns. Some patients report feeling satisfied with smaller portions, reduced cravings for high-calorie foods, and improved portion control. It is important to maintain adequate protein intake and continue drinking plenty of water during this adjustment period. Your Trimi care team is available through the patient portal if you have questions about side effects or need guidance on managing the transition.

Week 4: First Check-In & Progress Review

At the four-week mark, your Trimi physician conducts a progress review through the patient portal. You will report your current weight, any side effects you have experienced, and how you are feeling overall. Based on this information, the physician decides whether to maintain your current dose or begin the titration process to a higher dose. Most patients stay on the starting dose for at least four weeks before any increase. This check-in is also a good opportunity to ask questions about diet, exercise, and what to expect in month two. Your next medication refill is automatically coordinated so there is no gap in your treatment.

What to Remember: Weight loss with GLP-1 medications is gradual and varies by individual. Some patients see noticeable changes in the first month, while others may not see significant scale movement until month two or three when doses increase. The first month is primarily about building the habit, letting your body adjust, and establishing a strong foundation for long-term success.

Ready to Get Started?

Complete your free medical assessment in about 10 minutes. There's no obligation—you're only charged if approved and you choose to proceed.

Start Your Free Assessment

No credit card required until prescription is approved

Sources & References

Wilding JPH et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. NEJM 2021;384:989-1002.
Jastreboff AM et al. Tirzepatide Once Weekly for the Treatment of Obesity. NEJM 2022;387:205-216.
Lincoff AM et al. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes. NEJM 2023;389:2221-2232.
FDA Prescribing Information for Wegovy (semaglutide) and Zepbound (tirzepatide).

Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before starting any medication or treatment program.