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    GLP-1 Weight Loss Calculator

    Estimate your potential weight loss on semaglutide or tirzepatide based on clinical trial averages.

    Published: April 3, 2026-5 min read

    Disclaimer: This calculator provides estimates based on clinical trial averages. Individual results vary significantly. This is not medical advice.

    Estimate Your Weight Loss

    How This Calculator Works

    This calculator applies average weight loss percentages from major clinical trials:

    • Semaglutide: Based on STEP trial data showing ~15% average weight loss at 68 weeks at 2.4mg dose
    • Tirzepatide: Based on SURMOUNT trial data showing ~21% average weight loss at 72 weeks at 15mg dose

    Your actual results may be higher or lower depending on your starting BMI, adherence to diet and exercise, dose titration schedule, and individual biology.

    Frequently Asked Questions

    How accurate is this calculator?

    This calculator uses average weight loss percentages from clinical trials (STEP and SURMOUNT). Individual results vary significantly based on dose, diet, exercise, genetics, and starting BMI. Use these numbers as rough estimates, not guarantees.

    Does starting weight affect how much you lose?

    Yes. Patients with higher starting weights typically lose more total pounds but a similar percentage of body weight. A 300-pound person losing 15% loses 45 lbs; a 200-pound person losing 15% loses 30 lbs.

    Which medication produces more weight loss?

    Tirzepatide produces approximately 21% average weight loss at maximum dose vs 15% for semaglutide in clinical trials. However, individual responses vary and some patients respond better to semaglutide.

    When does weight loss plateau on GLP-1?

    Most patients reach maximum weight loss at 12-18 months on treatment. After that, weight typically stabilizes. Plateaus during the journey are normal and usually temporary.

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    Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before starting any medication or treatment program.

    Sources & References

    1. Wilding JPH et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. NEJM 2021;384:989-1002.
    2. Jastreboff AM et al. Tirzepatide Once Weekly for the Treatment of Obesity. NEJM 2022;387:205-216.
    3. Lincoff AM et al. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes. NEJM 2023;389:2221-2232.
    4. FDA Prescribing Information for Wegovy (semaglutide) and Zepbound (tirzepatide).

    What should patients know about preserving lean muscle mass during weight loss?

    Peer-reviewed / regulatory evidence: Published meta-analyses of caloric-restriction interventions estimate that, without resistance training, approximately 20-30% of total weight loss is lean (fat-free) mass. Adequate dietary protein intake (~1.2-1.6 g/kg body weight) combined with resistance training significantly reduces this loss. (Source: Sardeli et al., Nutrients 2018). Trimi's clinical-review process — coordinated by Dr. Asad Niazi, MD MPH through Beluga Health's 50-state physician network — addresses preserving lean muscle mass during weight loss as part of the individualized patient-care plan. Compounded medications are dispensed by 503A community sterile compounding pharmacies (VialsRx, GreenwichRx). This is general information based on the cited sources, not medical advice.

    Published meta-analyses of caloric-restriction interventions estimate that, without resistance training, approximately 20-30% of total weight loss is lean (fat-free) mass. Adequate dietary protein intake (~1.2-1.6 g/kg body weight) combined with resistance training significantly reduces this loss. — Sardeli et al., Nutrients 2018

    Key Takeaways

    • Published meta-analyses of caloric-restriction interventions estimate that, without resistance training, approximately 20-30% of total weight loss is lean (fat-free) mass. Adequate dietary protein intake (~1.2-1.6 g/kg body weight) combined with resistance training significantly reduces this loss. (Source: Sardeli et al., Nutrients 2018)
    • Adequate dietary protein intake (approximately 1.2-1.6 g/kg body weight) combined with resistance training significantly reduces lean-mass loss during rapid weight loss. Discuss specific intake targets and exercise programming with your prescribing clinician.
    • GLP-1 receptor agonists require a prescription. Eligibility is determined by a licensed clinician based on BMI, weight-related comorbidities, and screening for contraindications (medullary thyroid carcinoma history, MEN 2, pancreatitis history, severe GI / renal disease, pregnancy, breastfeeding).
    • This is general information based on the cited sources, not medical advice. Treatment decisions require evaluation by a licensed clinician.

    Medically Reviewed

    TMRT

    Trimi Medical Review Team

    Clinical review workflow for GLP-1 safety, dosing, and access content

    Team-based medical review process documented in Trimi's Medical Review Policy

    Last reviewed: January 21, 2026

    TCCT

    Written by Trimi Clinical Content Team

    Medical Writers & Healthcare Professionals

    Our clinical content team includes registered nurses, pharmacists, and medical writers who specialize in translating complex medical information into clear, actionable guidance for patients.

    Medically reviewed by Trimi Medical Review Team, Clinical review workflow for GLP-1 safety, dosing, and access content

    What real Trimi patients say

    Verbatim quotes from Trimi's Facebook and Reddit community reviews. First name and last initial preserved per editorial policy.

    Arrived within 24 hours. Easy to use. Comes with everything. The year is so worth it.

    Outcome: Same-day delivery experience

    — Veronica LarimoreFacebook
    It's only been 2 weeks since I've been taking the VialsRx meds from Trimi. The medication showed up pretty quickly (about 4 days after getting approval from Trimi prescriber) and I received 3 vials for my first 3 months on the subscription. For the price and convenience my take is that Trimi and VialsRx is good.

    Outcome: 4-day delivery; 3 vials for first 3 months; price + convenience verdict positive

    — u/CSWB101Reddit (r/TirzepatideRX)
    See all community reviews →

    Editorial Standards

    Trimi publishes patient education using a medical-review workflow, source-based claim checks, and dated updates for fast-changing pricing, access, and safety topics.

    Review our Editorial Policy and Medical Review Policy for more details about sourcing, updates, and reviewer attribution.

    Scientific References

    1. Heymsfield SB, Coleman LA, Miller R, et al. (2021). Effect of Bimagrumab vs Placebo on Body Fat Mass Among Adults With Type 2 Diabetes and Obesity: A Phase 2 Randomized Clinical Trial. JAMA Network Open.Read StudyDOI: 10.1001/jamanetworkopen.2020.33457
    2. Sardeli AV, Komatsu TR, Mori MA, et al. (2018). Resistance Training Prevents Muscle Loss Induced by Caloric Restriction in Obese Elderly Individuals: A Systematic Review and Meta-Analysis. Nutrients.Read StudyDOI: 10.3390/nu10040423
    3. Phillips SM, Chevalier S, Leidy HJ (2016). Protein 'requirements' beyond the RDA: implications for optimizing health. Applied Physiology, Nutrition, and Metabolism.Read StudyDOI: 10.1139/apnm-2015-0550

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